Description

2-Azabicyclo[2.2.2]Octane-2-Carboxylic Acid, 5-Hydroxy-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex bicyclic structure. This compound is of significant value for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug molecules, particularly in central nervous system (CNS) and antiviral research.
• Organic Synthesis Building Block: Utilized in asymmetric synthesis and medicinal chemistry for constructing sophisticated molecular architectures.
• Research & Development (R&D): Serves as a key reagent in academic and industrial laboratories for exploring new chemical entities and reaction pathways.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for target compounds in pilot plants and manufacturing.
• Catalyst and Ligand Precursor: Its structural features make it a potential precursor for novel catalysts or ligands in asymmetric catalysis.

Basic Information

Product Name	2-Azabicyclo[2.2.2]Octane-2-Carboxylic Acid, 5-Hydroxy-, 1,1-Dimethylethyl Ester
CAS No.	750634-09-4
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	tert-Butyl 5-hydroxy-2-azabicyclo[2.2.2]octane-2-carboxylate; 2-Azabicyclo[2.2.2]octane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester; 5-Hydroxy-2-azabicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester; (1R,4R,5R)-tert-Butyl 5-hydroxy-2-azabicyclo[2.2.2]octane-2-carboxylate (enantiomer); 2-N-Boc-5-hydroxy-2-azabicyclo[2.2.2]octane
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[2.2.2]Octane-2-Carboxylic Acid, 5-Hydroxy-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.