Description

4-Iodo-2-Trifluoromethyl-Nicotinic Acid is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its unique structure, combining a nicotinic acid core with iodine and trifluoromethyl substituents, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of advanced polymers and liquid crystals with specific electronic or optical properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl and conjugated systems.
• Fluorine Chemistry: Acts as a source of a trifluoromethylated pyridine moiety, which is valuable in medicinal chemistry for improving metabolic stability and membrane permeability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and protein-ligand interactions.

Basic Information

Product Name	4-Iodo-2-Trifluoromethyl-Nicotinic Acid
CAS No.	749875-19-2
Molecular Formula	C7H3F3INO2
Molecular Weight	316.99 g/mol
Synonyms	4-Iodo-2-(trifluoromethyl)nicotinic acid; 2-(Trifluoromethyl)-4-iodonicotinic acid; 4-Iodo-2-trifluoromethylpyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 4-iodo-2-(trifluoromethyl)-; 749875-19-2; 4-Iodo-2-trifluoromethyl-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Iodo-2-Trifluoromethyl-Nicotinic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical intermediate grade meets stringent internal specifications, supported by a detailed Certificate of Analysis (COA) for each lot. We support cGMP compliance for advanced applications, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.