Description

6-Bromo-2-(trifluoromethyl)nicotinic acid is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for medicinal chemistry and agrochemical research, enabling the rapid synthesis of complex molecules with enhanced biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials and liquid crystals due to its unique electronic properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic and Industrial R&D: Used in exploratory chemistry for method development and library synthesis in high-throughput screening.

Basic Information

Product Name	6-Bromo-2-(trifluoromethyl)nicotinic Acid
CAS No.	749875-13-6
Molecular Formula	C7H3BrF3NO2
Molecular Weight	269.99 g/mol
Synonyms	6-Bromo-2-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Bromo-5-(trifluoromethyl)picolinic acid; 2-Trifluoromethyl-6-bromonicotinic acid; 6-Bromo-2-trifluoromethylnicotinic acid; 749875-13-6; Nicotinic acid, 6-bromo-2-(trifluoromethyl)-; 3-Carboxy-6-bromo-2-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-(trifluoromethyl)nicotinic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to supply chain integrity and documentation transparency supports our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.