Description

3-Chloro-4-Iodo-2-(Trifluoromethyl)Pyridine is a high-value, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring chlorine, iodine, and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogenated pyridine core contributes to biological activity and metabolic stability.
• Material Science Precursor: Employed in the synthesis of functionalized ligands for catalysis and as a building block for organic electronic materials, such as those used in OLEDs.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig) to create complex biaryl and heteroaryl systems.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of chemical probes and affinity tags due to its reactive halogen sites.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs serving the life sciences sector.

Basic Information

Product Name	3-Chloro-4-Iodo-2-(Trifluoromethyl)Pyridine
CAS No.	749875-03-4
Molecular Formula	C6H2ClF3IN
Molecular Weight	321.44 g/mol
Synonyms	3-Chloro-4-iodo-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-3-chloro-4-iodopyridine; 4-Iodo-3-chloro-2-trifluoromethylpyridine; Pyridine, 3-chloro-4-iodo-2-(trifluoromethyl)-; 749875-03-4
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Iodo-2-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.