Description

1-Azaspiro[4.5]Dec-7-Ene-7-Carboxylic Acid, 8-Hydroxy-2-Oxo-, Methyl Ester is a high-value, complex heterocyclic building block and advanced pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel bioactive molecules and active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Used in the discovery and optimization of new chemical entities (NCEs) and lead compounds for various therapeutic areas.
• API Synthesis: Serves as a precursor in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) requiring a spirocyclic or constrained heterocyclic scaffold.
• Chemical Biology Probes: Employed in the development of specialized probes and tool compounds for studying biological pathways and target engagement.
• Fine Chemical Manufacturing: Used in the production of high-value, low-volume specialty chemicals for advanced applications.
• Contract Research & Development (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	1-Azaspiro[4.5]Dec-7-Ene-7-Carboxylic Acid, 8-Hydroxy-2-Oxo-, Methyl Ester
CAS No.	749861-28-7
Molecular Formula	C11H15NO4
Molecular Weight	225.24 g/mol
Synonyms	Methyl 8-hydroxy-2-oxo-1-azaspiro[4.5]dec-7-ene-7-carboxylate; 1-Azaspiro[4.5]dec-7-ene-7-carboxylic acid, 8-hydroxy-2-oxo-, methyl ester; 8-Hydroxy-2-oxo-1-azaspiro[4.5]dec-7-ene-7-carboxylic acid methyl ester; Spirocyclic lactam ester; Azaspirodecene carboxylate ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 1-Azaspiro[4.5]Dec-7-Ene-7-Carboxylic Acid, 8-Hydroxy-2-Oxo-, Methyl Ester adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.