Description

1-Azaspiro[4.5]Decane-2,8-Dione is a high-purity, versatile spirocyclic lactam building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key scaffold in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Ligand & Catalyst Development: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Incorporated into polymers and specialty coatings to impart specific thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Academic & Contract Research: Essential for methodological development and exploring new chemical space in university and CRO laboratories.

Basic Information

Product Name	1-Azaspiro[4.5]Decane-2,8-Dione
CAS No.	749861-03-8
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	2,8-Dioxo-1-azaspiro[4.5]decane; 1-Azaspiro[4.5]decane-2,8-dione; Spiro[cyclohexane-1,3'-pyrrolidine]-2',5'-dione; 2,8-Diazaspiro[4.5]decane-3,9-dione (common misnomer); 1-Aza-spiro[4.5]decane-2,8-dione; 749861-03-8; 1-Azaspiro[4,5]decane-2,8-dione
EINECS	Contact for details

Quality Control

Our 1-Azaspiro[4.5]Decane-2,8-Dione is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade starting materials and research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.