Description

2-Amino-5-Bromo-3-Fluoropyridine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring amino, bromo, and fluoro substituents, makes it an exceptionally versatile intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science sectors, where it is used to introduce key functional groups and modulate biological activity or material characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the halogenated pyridine core for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Precursor: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A valuable building block for medicinal chemistry, process chemistry, and exploratory synthesis in academic and industrial labs.
• Fluorine Chemistry: The presence of the fluorine atom makes it a useful compound for studying structure-activity relationships (SAR) and metabolic stability in drug discovery.

Basic Information

Item	Details
Product Name	2-Amino-5-Bromo-3-Fluoropyridine
CAS No.	748812-37-5
Molecular Formula	C5H4BrFN2
Molecular Weight	191.00 g/mol
Synonyms	5-Bromo-3-fluoro-pyridin-2-ylamine; 3-Fluoro-5-bromopyridin-2-amine; 2-Amino-3-fluoro-5-bromopyridine; 5-Bromo-3-fluoropyridin-2-amine; 2-Pyridinamine, 5-bromo-3-fluoro-; 748812-37-5; 5-Bromo-3-fluoro-2-aminopyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-5-Bromo-3-Fluoropyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support applications in GMP-intermediate and other regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.