Description

[1-(4-Trifluoromethylphenyl)-1-Tosyl]Methyl Isocyanide is a specialized organic building block featuring both a trifluoromethylphenyl group and a tosyl-protected methyl isocyanide moiety. This compound is valued for its unique reactivity as an isocyanide component in multicomponent reactions, enabling the efficient synthesis of complex heterocyclic and peptidomimetic scaffolds. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced medicinal chemistry and lead optimization programs.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of novel drug candidates, particularly in multicomponent reactions like the Ugi and Passerini reactions.
• Agrochemical Research: Used to construct complex molecular architectures for developing new active ingredients with enhanced properties.
• Chemical Biology Probes: Serves as a building block for creating isocyanide-based probes and tags for studying biological systems.
• Material Science: Potential precursor for functionalized polymers or organic electronic materials due to its aromatic and reactive groups.
• Academic & R&D: Employed in methodological research to discover new synthetic pathways and catalytic processes.

Basic Information

Product Name	[1-(4-Trifluoromethylphenyl)-1-Tosyl]Methyl Isocyanide
CAS No.	748187-71-5
Molecular Formula	C16H12F3NO2S
Molecular Weight	339.33 g/mol
Synonyms	1-Isocyano-1-(4-trifluoromethylphenyl)-1-tosylmethane; 1-Tosyl-1-(4-(trifluoromethyl)phenyl)methyl isocyanide; (4-Methylphenyl)sulfonyl(4-(trifluoromethyl)phenyl)methyl isocyanide; Tosyl(4-trifluoromethylphenyl)methyl isocyanide; [Tosyl(4-trifluoromethylphenyl)methyl]isocyanide; α-Isocyano-α-tosyl-4-(trifluoromethyl)toluene; (p-Tolylsulfonyl)(4-trifluoromethylphenyl)methyl isocyanide
EINECS	Contact for details

Quality Control

Our [1-(4-Trifluoromethylphenyl)-1-Tosyl]Methyl Isocyanide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from HPLC, NMR, and IR spectroscopy are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.