Description

L-Proline, 5,5-Dimethyl-, Methyl Ester (9Ci) is a high-purity, non-proteinogenic proline derivative characterized by its unique dimethyl substitution at the 5-position and methyl ester functional group. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering significant value in the development of complex molecules with tailored stereochemistry. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and specialty chemical sectors for applications ranging from peptide mimetics to novel active ingredient discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and peptide-based therapeutic research.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where specific stereochemistry influences biological activity.
• Peptidomimetics & Constrained Peptides: Incorporates conformational constraints into peptide backbones to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Acts as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Specialty Polymer & Material Science: A potential monomer for creating novel polymers with specific functional properties derived from its proline scaffold.

Basic Information

Product Name	L-Proline, 5,5-Dimethyl-, Methyl Ester (9Ci)
CAS No.	747407-19-8
Molecular Formula	C9H17NO3
Molecular Weight	187.24 g/mol
Synonyms	Methyl (2S)-5,5-dimethylpyrrolidine-2-carboxylate; L-5,5-Dimethylproline methyl ester; (S)-5,5-Dimethylproline methyl ester; 5,5-Dimethyl-L-proline methyl ester; Methyl 5,5-dimethyl-L-prolinate; Pyrrolidine-2-carboxylic acid, 5,5-dimethyl-, methyl ester, (2S)-; Proline, 5,5-dimethyl-, methyl ester, L-
EINECS	Contact for details

Quality Control

Our L-Proline, 5,5-Dimethyl-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.