Description

3-Methyl-3H-Spiro[Isobenzofuran-1,4'-Piperidine] Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Drug Discovery & Medicinal Chemistry: Used in research libraries and for structure-activity relationship (SAR) studies to optimize lead compounds.
• Process Chemistry & Scale-Up: Serves as a critical raw material for process development and cGMP manufacturing of APIs.
• Biochemical Research: Employed as a ligand or probe in the study of specific biological receptors and pathways.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	3-Methyl-3H-Spiro[Isobenzofuran-1,4'-Piperidine] Hydrochloride
CAS No.	747353-15-7
Molecular Formula	C14H17NO2·HCl
Molecular Weight	267.75 g/mol
Synonyms	3-Methyl-3H-spiro[2-benzofuran-1,4'-piperidine] hydrochloride; 3-Methyl-3H-spiro[isobenzofuran-1,4'-piperidine] HCl; 3-Methylspiro[isobenzofuran-1(3H),4'-piperidine] hydrochloride; 747353-15-7; Spiro[isobenzofuran-1(3H),4'-piperidine], 3-methyl-, hydrochloride; 3-Methyl-1-oxa-2-azaspiro[4.5]deca-2,6,9-trien-8-one hydrochloride (non-IUPAC); 3-Methyl-3H-spiro[2-benzofuran-1,4'-piperidinium] chloride
EINECS	Contact for details

Quality Control

Our 3-Methyl-3H-Spiro[Isobenzofuran-1,4'-Piperidine] Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.