Description

(1R,2R)-(-)-2-Benzyloxycyclohexyl Isocyanate is a chiral, enantiomerically pure isocyanate derivative of cyclohexanol. This compound is a valuable chiral building block in asymmetric synthesis, prized for its ability to introduce stereochemistry into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and advanced intermediates.

Application

• Chiral Auxiliary and Building Block: A key intermediate in the synthesis of enantiomerically pure pharmaceuticals and agrochemicals.
• Asymmetric Synthesis: Used in the preparation of chiral ureas, carbamates, and other derivatives via reactions with amines and alcohols.
• Pharmaceutical Research: Employed in medicinal chemistry for the development of novel drug candidates, particularly those requiring specific stereochemistry for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Polymer Science: Can be used to introduce chiral centers into specialty polymers, such as polyurethanes and polyureas, for advanced material properties.
• Chemical Biology: Useful for the site-specific labeling or modification of biomolecules through isocyanate chemistry.

Basic Information

Product Name	(1R,2R)-(-)-2-Benzyloxycyclohexyl Isocyanate
CAS No.	745784-13-8
Molecular Formula	C14H17NO2
Molecular Weight	231.29 g/mol
Synonyms	(1R,2R)-2-(Benzyloxy)cyclohexyl isocyanate; (-)-trans-2-Benzyloxycyclohexyl isocyanate; (1R,2R)-(-)-2-(Phenylmethoxy)cyclohexyl isocyanate; trans-2-Benzyloxycyclohexyl isocyanate; (1R,2R)-2-Benzyloxycyclohexyl isocyanate; Benzyl (1R,2R)-2-isocyanatocyclohexyl ether; Cyclohexanol, 2-(benzyloxy)-, 1-isocyanate, (1R,2R)-
EINECS	Contact for details

Quality Control

Our (1R,2R)-(-)-2-Benzyloxycyclohexyl Isocyanate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical and enantiomeric purity, meeting the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.