Description

Benzene, 1-[(1R)-1-Isocyanatoethyl]-3-Methoxy- (9Ci) is a specialized chiral isocyanate derivative, a high-value building block in advanced organic synthesis. This compound is critical for introducing the (R)-1-isocyanatoethyl functional group into target molecules with precise stereochemical control. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, chiral ligands, and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced, stereospecific pesticides and herbicides where biological activity is enantiomer-dependent.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Material Science: Employed in the creation of specialty polyurethanes and polymers with tailored properties, such as chiral stationary phases for chromatography.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation, labeling proteins, or modifying biomolecules in research applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Benzene, 1-[(1R)-1-Isocyanatoethyl]-3-Methoxy- (9Ci)
CAS No.	745784-07-0
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	(R)-1-Isocyanato-1-(3-Methoxyphenyl)ethane; 1-[(1R)-1-Isocyanatoethyl]-3-Methoxybenzene; (R)-α-Methyl-3-methoxybenzyl isocyanate; (R)-1-(3-Methoxyphenyl)ethyl isocyanate; 3-Methoxy-(R)-α-methylbenzyl isocyanate; (R)-MOPEIC; (R)-1-(3-Methoxyphenyl)ethyl isocyanate
EINECS	Contact for details

Quality Control

Our production of Benzene, 1-[(1R)-1-Isocyanatoethyl]-3-Methoxy- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for chiral applications. All materials are characterized by advanced analytical techniques including chiral HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess (ee), and impurity profile is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at recommended temperatures (typically 2-8°C for extended stability). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and polymerization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (Assay by GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF Titration)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.