Description

(R)-(-)-3-Methyl-2-Butyl Isocyanate CAS NO 745783-84-0 is a high-purity, chiral isocyanate building block essential for the synthesis of enantiomerically pure compounds. Its value lies in its role as a key intermediate for introducing the (R)-3-methyl-2-butyl moiety into complex molecules, enabling precise control over stereochemistry in advanced research and development. This compound is primarily needed by pharmaceutical researchers and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where optical purity is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of enantiomerically pure active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Modification: Employed to introduce chiral centers into specialty polymers and polyurethanes for advanced material properties.
• Peptidomimetics Research: Utilized in medicinal chemistry for constructing non-natural amino acid derivatives and peptide analogs.
• Chemical Biology Probes: Acts as a building block for creating labeled or tagged molecules used in biochemical and cellular studies.

Basic Information

Product Name	(R)-(-)-3-Methyl-2-Butyl Isocyanate
CAS No.	745783-84-0
Molecular Formula	C6H11NO
Molecular Weight	113.16 g/mol
Synonyms	(R)-3-Methyl-2-butyl isocyanate; (R)-(-)-3-Methylbutan-2-yl isocyanate; (2R)-3-Methyl-2-butyl isocyanate; (R)-sec-Isoamyl isocyanate; (R)-1-Isocyanato-3-methylbutane-2-yl; (R)-1-Isocyanato-3-methylbutan-2-yl; (R)-3-Methyl-2-butanyl isocyanate
EINECS	Contact for details

Quality Control

Our (R)-(-)-3-Methyl-2-Butyl Isocyanate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC and GC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.