Description

Benzene, 1-[(1R)-1-Isocyanatoethyl]-4-Methoxy- (9Ci) is a specialized chiral isocyanate derivative, a high-value building block for advanced organic synthesis. Its core value lies in enabling the precise introduction of a reactive isocyanate group with defined stereochemistry, which is critical for creating molecules with specific biological or material properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in advanced materials science for creating functional polymers and coatings. CAS number 745783-82-8.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Agrochemical Synthesis: Used in the research and development of advanced, stereospecific pesticides and herbicides.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialized polyurethanes, polyureas, and other functional polymers with tailored properties.
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein interactions.
• Custom Synthesis & R&D: A critical reagent for contract research organizations (CROs) and academic laboratories engaged in cutting-edge organic chemistry.

Basic Information

Product Name	Benzene, 1-[(1R)-1-Isocyanatoethyl]-4-Methoxy- (9Ci)
CAS No.	745783-82-8
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	(1R)-1-Isocyanato-1-(4-methoxyphenyl)ethane; (R)-1-(4-Methoxyphenyl)ethyl isocyanate; p-Methoxy-(R)-α-methylbenzyl isocyanate; (R)-1-Isocyanatoethyl-4-methoxybenzene; (R)-1-(4-Methoxyphenyl)ethyl isocyanate; (R)-p-Methoxy-α-methylbenzyl isocyanate; (R)-MBI; Chiral 4-Methoxy-α-methylbenzyl isocyanate
EINECS	Contact for details

Quality Control

Every batch of Benzene, 1-[(1R)-1-Isocyanatoethyl]-4-Methoxy- (9Ci) is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure high chiral purity and chemical integrity, critical for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC/GC), chiral excess, and impurity profiles are available for each lot. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from heat, open flames, and incompatible materials such as alcohols, amines, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.