Description

Benzene, 1-Fluoro-4-[(1R)-1-Isocyanatoethyl]- (9Ci) is a chiral aromatic isocyanate derivative, a high-value building block in advanced organic synthesis. This compound matters for its dual functionality, combining a reactive isocyanate group with a fluorinated benzene ring, enabling the precise construction of complex molecules with tailored properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides with enhanced efficacy and environmental profiles.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes.
• Polymer & Resin Modification: Employed to introduce fluorinated aromatic and urethane linkages into specialty polymers, improving chemical resistance and thermal stability.
• Cross-linking Agent: Functions as a reactive moiety in the synthesis of cross-linked polymers, coatings, and adhesives for high-performance applications.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new fluorinated compounds and isocyanate chemistry.

Basic Information

Product Name	Benzene, 1-Fluoro-4-[(1R)-1-Isocyanatoethyl]- (9Ci)
CAS No.	745783-73-7
Molecular Formula	C9H8FNO
Molecular Weight	165.17 g/mol
Synonyms	1-Fluoro-4-[(1R)-1-isocyanatoethyl]benzene; (R)-1-(4-Fluorophenyl)ethyl isocyanate; p-Fluoro-(R)-α-methylbenzyl isocyanate; (R)-1-Isocyanato-1-(4-fluorophenyl)ethane; 4-Fluoro-(R)-α-methylbenzyl isocyanate; (R)-1-(4-Fluorophenyl)ethanyl isocyanate; Benzene, 1-fluoro-4-[(1R)-1-isocyanatoethyl]-
EINECS	Contact for details

Quality Control

Every batch of Benzene, 1-Fluoro-4-[(1R)-1-Isocyanatoethyl]- (9Ci) is produced and analyzed under strict quality protocols to ensure high chemical purity and enantiomeric excess. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for identity, purity, and chiral purity (typically by chiral HPLC).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis of the isocyanate group. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.