Description

(R)-(+)-1-(4-Chlorophenyl)Ethyl Isocyanate is a high-purity chiral isocyanate building block essential for asymmetric synthesis. This compound matters for its role as a key intermediate in the development of enantiomerically pure pharmaceuticals and advanced agrochemicals. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the (R)-1-(4-chlorophenyl)ethyl moiety into target molecules with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of chiral active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators where specific stereochemistry is required for bioactivity.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing chiral auxiliaries, ligands for asymmetric catalysis, and organocatalysts.
• Advanced Material Research: Employed in the development of specialty polymers and liquid crystals with tailored optical or mechanical properties.
• Custom Synthesis & Contract Manufacturing: A valuable building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic & Industrial R&D: Utilized in research laboratories for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	(R)-(+)-1-(4-Chlorophenyl)Ethyl Isocyanate
CAS No.	745783-71-5
Molecular Formula	C9H8ClNO
Molecular Weight	181.62 g/mol
Synonyms	(R)-1-(4-Chlorophenyl)ethyl isocyanate; (R)-(+)-1-(p-Chlorophenyl)ethyl isocyanate; (R)-α-Methyl-4-chlorobenzyl isocyanate; (+)-(R)-1-(4-Chlorophenyl)ethyl isocyanate; (R)-1-(4-Chlorophenyl)ethan-1-yl isocyanate; (R)-CEIC; p-Chloro-α-methylbenzyl isocyanate (R-enantiomer)
EINECS	Contact for details

Quality Control

Our (R)-(+)-1-(4-Chlorophenyl)Ethyl Isocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and purity assessment, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from heat, open flames, and sources of ignition. Isocyanate compounds should be stored separately from amines, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.