Description

Carbamic Acid, [(1S)-2-[(5-Bromo-2-Thiazolyl)Amino]-1-Methyl-2-Oxoethyl]-, 1,1-Dimethylethyl Ester (9Ci) is a specialized chiral building block and advanced pharmaceutical intermediate of significant interest in modern synthetic chemistry. Its core value lies in its unique molecular architecture, which incorporates a bromothiazole moiety and a protected carbamate group, making it a versatile precursor for the development of targeted bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules with potential therapeutic or pesticidal activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology, antiviral, and anti-inflammatory drug discovery programs.
• Agrochemical Research: Serves as a crucial building block for developing new generation pesticides and herbicides, leveraging the bioactive thiazole ring system.
• Chemical Biology Probe: Used in medicinal chemistry to create molecular probes for studying enzyme inhibition and receptor-ligand interactions.
• Peptidomimetics Synthesis: The protected amino acid-like structure makes it valuable for constructing non-natural peptide analogs and peptidomimetic compounds.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthesis to introduce complex molecular features with high enantiomeric purity.
• Material Science Research: Potential precursor for specialty polymers or functional materials that require specific heterocyclic components.

Basic Information

Product Name	Carbamic Acid, [(1S)-2-[(5-Bromo-2-Thiazolyl)Amino]-1-Methyl-2-Oxoethyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	742700-34-1
Molecular Formula	C11H16BrN3O3S
Molecular Weight	350.23 g/mol
Synonyms	tert-Butyl (2S)-2-[(5-bromo-1,3-thiazol-2-yl)amino]-2-methyl-3-oxopropanoate; (2S)-2-[(5-Bromo-2-thiazolyl)amino]-2-methyl-3-oxo-propanoic acid tert-butyl ester; (S)-tert-Butyl 2-((5-bromothiazol-2-yl)amino)-2-methyl-3-oxopropanoate; N-(5-Bromo-2-thiazolyl)-N-[(1S)-1-(tert-butoxycarbonyl)-1-methyl-2-oxoethyl]amine; 9CI-742700-34-1; Boc-D-Ala(5-Br-Thz)-OH (tert-butyl ester derivative); Advanced Bromothiazole Intermediate
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1S)-2-[(5-Bromo-2-Thiazolyl)Amino]-1-Methyl-2-Oxoethyl]-, 1,1-Dimethylethyl Ester (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive R&D and scale-up processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation. We support compliance with cGMP guidelines for advanced intermediates, and specifications can be aligned with client-specific requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). For long-term storage, consider holding under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.