Description

2,8-Diazaspiro[4.5]Decane-2-Carboxylic Acid, 8-(Methylsulfonyl)-, 1,1-Dimethylethyl Ester is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and diaza structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in pharmaceutical and biotechnology companies seeking to build sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring spirocyclic scaffolds for enhanced binding affinity and metabolic stability.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space for therapeutic targets.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development for potential Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Synthesis: The diazaspirodecane core is a privileged structure in the design of inhibitors for various enzymes, including proteases.
• Ligand and Catalyst Development: Potential use in creating novel chiral ligands or organocatalysts due to its nitrogen-containing, sterically defined architecture.

Basic Information

Product Name	2,8-Diazaspiro[4.5]Decane-2-Carboxylic Acid, 8-(Methylsulfonyl)-, 1,1-Dimethylethyl Ester
CAS No.	742067-22-7
Molecular Formula	C14H26N2O4S
Molecular Weight	318.44 g/mol
Synonyms	tert-Butyl 8-(methylsulfonyl)-2,8-diazaspiro[4.5]decane-2-carboxylate; 2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester; 8-Methanesulfonyl-2,8-diazaspiro[4.5]decane-2-carboxylic acid tert-butyl ester; 2-(tert-Butoxycarbonyl)-8-(methylsulfonyl)-2,8-diazaspiro[4.5]decane; Boc-8-(Ms)-2,8-diazaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our 2,8-Diazaspiro[4.5]Decane-2-Carboxylic Acid, 8-(Methylsulfonyl)-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.