Description

2-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure incorporating a trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering a versatile building block for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for lead optimization and the synthesis of complex target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used for lead compound optimization and structure-activity relationship (SAR) studies due to its trifluoromethylated naphthyridine scaffold.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new generation pesticides and herbicides.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme inhibition and biological pathways.
• Process Chemistry: Used in scale-up and route scouting for the commercial manufacturing of active ingredients.
• Academic Research: A valuable reagent for universities and research institutes exploring new heterocyclic chemistry and fluorinated compounds.

Basic Information

Product Name	2-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine Hydrochloride
CAS No.	741736-98-1
Molecular Formula	C9H10ClF3N2
Molecular Weight	238.64 g/mol
Synonyms	5,6,7,8-Tetrahydro-2-(trifluoromethyl)-1,6-naphthyridine hydrochloride; 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine HCl; 1,6-Naphthyridine, 5,6,7,8-tetrahydro-2-(trifluoromethyl)-, hydrochloride; 741736-98-1; CAS 741736-98-1
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.