Description

3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 741736-95-8. This compound is valued for its unique heterocyclic structure, which incorporates a trifluoromethyl group, a key motif known to enhance metabolic stability and bioavailability in active pharmaceutical ingredients (APIs). It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel therapeutic agents and crop protection chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Synthesis: Employed in the final stages or as a key precursor in the manufacturing process of active pharmaceutical ingredients.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine Hydrochloride
CAS No.	741736-95-8
Molecular Formula	C9H10ClF3N2
Molecular Weight	238.64 g/mol
Synonyms	5,6,7,8-Tetrahydro-3-(trifluoromethyl)-1,6-naphthyridine hydrochloride; 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine HCl; 1,6-Naphthyridine, 5,6,7,8-tetrahydro-3-(trifluoromethyl)-, hydrochloride; 741736-95-8; 3-Trifluoromethyl-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-1,6-Naphthyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.