Description

Bempedoic Acid CAS NO 738606-46-7 is a small-molecule, orally-administered therapeutic agent that functions as an ATP-citrate lyase (ACL) inhibitor. This compound matters significantly as a next-generation lipid-lowering medication, offering a complementary mechanism of action to statins for managing hypercholesterolemia. It is primarily needed by pharmaceutical manufacturers and research institutions engaged in the development and production of cardiovascular disease treatments, as well as by contract research organizations (CROs) conducting preclinical and clinical studies.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of oral tablets for cholesterol management.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Pharmacological Research for studying ACL inhibition pathways and lipid metabolism.
• Drug Development for creating fixed-dose combination therapies with other lipid-modifying agents.
• Process Chemistry for scaling up synthesis and optimizing manufacturing routes.
• Regulatory Submissions, providing high-purity material for stability studies and dossier preparation.

Basic Information

Product Name	Bempedoic Acid
CAS No.	738606-46-7
Molecular Formula	C19H28ClNO5
Molecular Weight	409.89 g/mol
Synonyms	ETC-1002; ESP-55016; 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid; (8R,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol (IUPAC for core sterol structure related to synthesis); Bempedoiс Acid (alternate spelling); NSC-855107
EINECS	Contact for details

Quality Control

Our Bempedoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral methods for stereochemical integrity, and residual solvent analysis, to ensure compliance with ICH guidelines and customer-specific requirements. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Chiral Purity	≥99.0%
Residual Solvents (GC)	Complies with ICH Q3C Class 2 & 3 limits
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.