Description

Methanol, (3-Ethyl-1,4-Dioxaspiro[4.4]Non-2-Ylidene)Methoxy-, (R)- (9Ci) CAS NO 734497-47-3 is a specialized chiral building block featuring a spirocyclic dioxolane moiety, which is critical for imparting stereochemical control in advanced synthetic pathways. This compound is valued for its role as a key intermediate in the synthesis of complex, optically active molecules, particularly in pharmaceutical research and development. It is essential for chemists and manufacturers in the fine chemical, agrochemical, and advanced material sectors who require high-purity, stereodefined intermediates to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drugs.
• Agrochemical Synthesis: Used in the research and production of stereoselective pesticides and herbicides, where the specific configuration is vital for biological activity.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Employed in the multistep synthesis of complex natural products, flavors, and fragrances requiring precise stereochemistry.
• Material Science Research: Utilized in the development of chiral polymers and advanced organic materials with specific optical properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and process optimization in pilot-scale manufacturing.

Basic Information

Product Name	Methanol, (3-Ethyl-1,4-Dioxaspiro[4.4]Non-2-Ylidene)Methoxy-, (R)- (9Ci)
CAS No.	734497-47-3
Molecular Formula	C11H18O3
Molecular Weight	198.26 g/mol
Synonyms	(R)-Methoxy(3-ethyl-1,4-dioxaspiro[4.4]non-2-ylidene)methane; (R)-2-(Methoxymethylene)-3-ethyl-1,4-dioxaspiro[4.4]nonane; (R)-3-Ethyl-2-(methoxymethylene)-1,4-dioxaspiro[4.4]nonane; (R)-Spirocyclic dioxolane methanol derivative; (R)-Enol ether of spiroketal; Chiral spiro-dioxolane enol ether; (R)-734497-47-3
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for downstream synthetic applications. Quality is verified through advanced analytical techniques including Chiral HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be kept under an inert atmosphere if long-term storage is required to maintain stability. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.