Description

1-Methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 733757-93-2. This compound is a critical building block in modern medicinal chemistry, valued for its unique fused heterocyclic structure that incorporates a trifluoromethyl group, a key motif for enhancing the metabolic stability and bioavailability of drug candidates. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents targeting central nervous system disorders and other complex diseases.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of drug candidates.
• Preclinical Drug Development: Employed in the synthesis of compounds for in vitro and in vivo biological testing and toxicology studies.
• Process Chemistry & Scale-Up: Serves as a starting material for developing robust and cost-effective synthetic routes for potential commercial-scale API manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-Methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine hydrochloride
CAS No.	733757-93-2
Molecular Formula	C9H11ClF3N3
Molecular Weight	253.65 g/mol
Synonyms	1-Methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine HCl; 1-Methyl-3-(trifluoromethyl)-6,7-dihydro-1H,4H-pyrazolo[3,4-c]pyridine hydrochloride; 4,5,6,7-Tetrahydro-1-methyl-3-(trifluoromethyl)-1H-pyrazolo[3,4-c]pyridine hydrochloride; 733757-93-2; Pyrazolo[3,4-c]pyridine hydrochloride derivative; TFMPP derivative hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and desiccated to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.