Description

L-Proline, 2-Hydroxyethyl Ester (9Ci) is a high-purity, functionalized amino acid derivative designed for advanced chemical synthesis and pharmaceutical research. This compound is valued for its role as a versatile chiral building block, enabling the introduction of the proline moiety with an ester-linked hydroxyethyl side chain. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-mimetic drugs, prodrugs, and enzyme inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce modified proline residues, potentially altering peptide conformation and bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating novel, bioactive compounds with potential herbicidal or insecticidal properties.
• Bioconjugation & Linker Chemistry: The hydroxyethyl ester group can be utilized for further functionalization or as a cleavable linker in prodrug design and bioconjugate applications.
• Asymmetric Catalysis: May be employed as a precursor or ligand in the development of chiral catalysts for stereoselective transformations.
• Cosmetic & Personal Care Actives: Investigated for use in the synthesis of peptides and other ingredients aimed at skin conditioning and anti-aging formulations.

Basic Information

Product Name	L-Proline, 2-Hydroxyethyl Ester (9Ci)
CAS No.	733697-14-8
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	2-Hydroxyethyl L-prolinate; L-Prolinol, 2-hydroxy-; (S)-2-Hydroxyethyl pyrrolidine-2-carboxylate; Proline 2-hydroxyethyl ester; 2-Hydroxyethyl (S)-pyrrolidine-2-carboxylate; H-Pro-OCH2CH2OH; 733697-14-8 (CAS)
EINECS	Contact for details

Quality Control

Our L-Proline, 2-Hydroxyethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) documenting identity, purity (by HPLC), and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.