Description

4-Chloro-3-(Trifluoromethyl)Pyridine Hydrochloride is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and trifluoromethyl substituents, makes it an essential intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals, pharmaceuticals, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and electronic materials requiring specific fluorine-containing motifs.
• Chemical Biology Probes: Utilized as a building block for designing molecular probes and inhibitors for biochemical and pharmacological research.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethyl)Pyridine Hydrochloride
CAS No.	732306-24-0
Molecular Formula	C7H4ClF3N • HCl
Molecular Weight	232.47 g/mol (Free base: 195.56 g/mol)
Synonyms	4-Chloro-3-(trifluoromethyl)pyridine HCl; 3-Trifluoromethyl-4-chloropyridine hydrochloride; 4-Chloro-α,α,α-trifluoro-3-pyridinemethanol hydrochloride (related); Pyridine, 4-chloro-3-(trifluoromethyl)-, hydrochloride; 732306-24-0; 4-Chloro-3-trifluoromethylpyridinium chloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(Trifluoromethyl)Pyridine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, supporting your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.