Description

D-Proline, 4-Amino-1-Methyl-, Methyl Ester, (4S)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative with a defined stereochemistry. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereocontrol. It is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-quality, enantiomerically pure intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, peptidomimetics, and other bioactive compounds.
• Agrochemical Synthesis: Used in the research and production of enantiomerically pure pesticides and herbicides, where specific stereochemistry can be crucial for activity and environmental profile.
• Peptide Chemistry & Research: Employed as a modified proline derivative in peptide synthesis to study structure-activity relationships, create constrained peptides, or develop novel peptide-based therapeutics.
• Asymmetric Catalysis Ligand Precursor: Acts as a starting material for the synthesis of chiral ligands and organocatalysts used in asymmetric transformations.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes to study enzyme mechanisms, protein-protein interactions, and biological pathways.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological development in organic synthesis and for exploring new chemical space in discovery chemistry programs.

Basic Information

Product Name	D-Proline, 4-Amino-1-Methyl-, Methyl Ester, (4S)- (9Ci)
CAS No.	732241-85-9
Molecular Formula	C7H14N2O2
Molecular Weight	158.20 g/mol
Synonyms	(4S)-4-Amino-1-methylpyrrolidine-2-carboxylic acid methyl ester; Methyl (4S)-4-amino-1-methyl-D-prolinate; Methyl (2S,4S)-4-amino-1-methylpyrrolidine-2-carboxylate; D-4-Amino-1-methylproline methyl ester; (S)-Methyl 4-amino-1-methylpyrrolidine-2-carboxylate; 1-Methyl-4-amino-D-proline methyl ester; 732241-85-9
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Amino-1-Methyl-, Methyl Ester, (4S)- (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity (typically >97% by HPLC), and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.