Description

4-Pyridinepropanoic Acid, α-Fluoro-β-Oxo-, Ethyl Ester (9Ci) is a specialized fluorinated pyridine derivative that serves as a high-value synthetic intermediate. This compound is critical for introducing both fluorine and a reactive β-keto ester moiety into complex molecular architectures, enabling advanced research and development. It is primarily sought by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients and by fine chemical manufacturers producing custom intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Used in developing novel pesticides and herbicides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent for creating specialty polymers and advanced organic electronic materials.
• Fluorine Chemistry: A versatile reagent for introducing fluorine-containing functional groups in complex organic synthesis for academic and industrial research.
• Ligand Synthesis: Used in the preparation of novel chelating ligands for catalysis and metal-organic frameworks (MOFs).
• Bioconjugation: The reactive keto-ester group can be utilized for linking molecules in probe and diagnostic reagent development.

Basic Information

Product Name	4-Pyridinepropanoic Acid, α-Fluoro-β-Oxo-, Ethyl Ester (9Ci)
CAS No.	731770-29-9
Molecular Formula	C11H12FNO3
Molecular Weight	225.22 g/mol
Synonyms	Ethyl 2-Fluoro-3-oxo-3-(pyridin-4-yl)propanoate; 2-Fluoro-3-oxo-3-(4-pyridinyl)propanoic Acid Ethyl Ester; α-Fluoro-β-oxo-4-pyridinepropanoic Acid Ethyl Ester; 4-Pyridinepropanoic acid, 2-fluoro-3-oxo-, ethyl ester; Ethyl α-fluoro-β-oxo-4-pyridinepropionate; 731770-29-9; 4-Pyridinepropionic acid, α-fluoro-β-oxo-, ethyl ester
EINECS	Contact for details

Quality Control

Our 4-Pyridinepropanoic Acid, α-Fluoro-β-Oxo-, Ethyl Ester (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production use. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.