Description

6'-Chloro-1'H-Spiro[Piperidine-4,2'-Quinazolin]-4'(3'H)-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic quinazolinone core structure. This compound is of significant value for research and development in medicinal chemistry, particularly for its potential role as a key building block in the synthesis of novel bioactive molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, particularly those targeting protein kinases and other enzymatic pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing compound libraries in high-throughput screening (HTS) campaigns to identify new lead structures.
• Oncology Drug Development: Explored for the synthesis of novel small-molecule inhibitors due to the quinazolinone moiety's known affinity for certain cancer-related targets.
• CNS-Active Compound Synthesis: Investigated in the development of new neuropharmacological agents, leveraging the spirocyclic and piperidine structural elements.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying specific biological mechanisms and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this specialized intermediate.

Basic Information

Product Name	6'-Chloro-1'H-Spiro[Piperidine-4,2'-Quinazolin]-4'(3'H)-One
CAS No.	731762-03-1
Molecular Formula	C12H12ClN3O
Molecular Weight	249.70 g/mol
Synonyms	6'-Chloro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one; 6'-Chloro-3'H-spiro[piperidine-4,2'-quinazolin]-4'-one; Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one, 6'-chloro-1'H-; 731762-03-1; 6-Chloro-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one; 6'-Chloro-spiro(piperidine-4,2'-(1'H)quinazolin)-4'(3'H)-one
EINECS	Contact for details

Quality Control

Our production of 6'-Chloro-1'H-Spiro[Piperidine-4,2'-Quinazolin]-4'(3'H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized and released against comprehensive specifications, including identity confirmation by spectroscopic methods and purity determination by HPLC. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.