Description

4-Bromo-2-Chlorophenylisocyanide is a versatile aromatic isocyanide building block, essential for the synthesis of complex heterocyclic compounds and functional materials. Its unique reactivity profile makes it a critical reagent in modern organic and medicinal chemistry, enabling the construction of diverse molecular architectures. This high-purity intermediate is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science sectors for advanced R&D and process development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the creation of new active ingredients for crop protection agents, leveraging its halogenated aromatic structure.
• Material Science: Serves as a precursor for functional polymers, liquid crystals, and metal-organic frameworks (MOFs) due to its isocyanide functional group.
• Multicomponent Reactions (MCRs): An essential reactant in Passerini and Ugi-type reactions for the efficient, one-pot generation of compound libraries.
• Catalyst Ligand Synthesis: Employed in the preparation of specialized isocyanide ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in the development of activity-based probes and bio-conjugation tools for studying biological processes.

Basic Information

Product Name	4-Bromo-2-Chlorophenylisocyanide
CAS No.	730971-45-6
Molecular Formula	C7H3BrClN
Molecular Weight	216.46 g/mol
Synonyms	2-Chloro-4-bromophenyl isocyanide; 1-Bromo-3-chloro-4-isocyanobenzene; 4-Bromo-2-chlorobenzene isocyanide; 4-Bromo-2-chloro-1-isocyanobenzene; Isocyanide, (4-bromo-2-chlorophenyl)-; (4-Bromo-2-chlorophenyl)isocyanide
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chlorophenylisocyanide is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP and ISO standards for reliable, batch-to-batch consistency in critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.