Description

2,5-Dibromophenylisocyanide is a versatile aromatic isocyanide building block, primarily valued for its role as a key ligand in transition metal catalysis and as a precursor in multicomponent reactions. Its significance lies in enabling the synthesis of complex heterocyclic compounds and functional materials through efficient palladium-catalyzed cross-coupling and isocyanide insertion chemistry. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and advanced material science, where precise molecular construction is critical.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel drug candidates, particularly in the construction of nitrogen-containing heterocycles via Ugi and Passerini reactions.
• Catalyst Ligand Synthesis: Used to prepare specialized isocyanide ligands for palladium, rhodium, and other transition metal catalysts, enhancing reaction selectivity and efficiency.
• Agrochemical Research: Employed in the development of new active ingredients for crop protection agents, leveraging its reactivity to create diverse molecular scaffolds.
• Material Science: Acts as a monomer or functionalization agent in the creation of conductive polymers, metal-organic frameworks (MOFs), and other functional organic materials.
• Chemical Biology & Probe Development: Utilized in the synthesis of activity-based probes and bio-conjugation reagents due to the unique reactivity of the isocyanide group.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic synthesis, enabling new routes to complex molecules.

Basic Information

Product Name	2,5-Dibromophenylisocyanide
CAS No.	730971-44-5
Molecular Formula	C7H3Br2N
Molecular Weight	260.91 g/mol
Synonyms	1,4-Dibromo-2-isocyanobenzene; 2,5-Dibromophenyl isocyanide; 2,5-Dibromobenzene isocyanide; 2,5-Dibromo-1-isocyanobenzene; Isocyanic acid, 2,5-dibromophenyl ester; 2,5-Dibromophenyl iso-cyanide; (2,5-Dibromophenyl)isocyanide
EINECS	Contact for details

Quality Control

Our 2,5-Dibromophenylisocyanide is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. We are committed to supplying material that meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the reactive nature of isocyanides, it is recommended to store under an inert atmosphere for long-term stability and to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.