Description

2-Bromo-4-Methylphenylisocyanide is a versatile and highly reactive organic building block characterized by its isocyanide functional group. This compound is crucial for the synthesis of complex heterocycles and functional materials, offering a key entry point into multicomponent reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of bioactive molecules, heterocyclic compounds, and potential drug candidates via multicomponent reactions like the Ugi and Passerini reactions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactivity to create diverse chemical scaffolds.
• Ligand Synthesis in Catalysis: Serves as a precursor for the preparation of specialized isocyanide-based ligands used in transition metal catalysis and organometallic chemistry.
• Material Science: Employed in the creation of functional polymers, metal-organic frameworks (MOFs), and other advanced materials where the isocyanide group can act as a linker or functional handle.
• Chemical Biology & Probe Development: Useful for labeling and modifying biomolecules, enabling the study of biological processes and the development of diagnostic tools.

Basic Information

Product Name	2-Bromo-4-Methylphenylisocyanide
CAS No.	730971-43-4
Molecular Formula	C8H6BrN
Molecular Weight	196.05 g/mol
Synonyms	2-Bromo-4-methylphenyl isocyanide; 1-Bromo-3-isocyano-4-methylbenzene; 2-Bromo-p-tolyl isocyanide; 4-Methyl-2-bromophenyl isocyanide; Isocyanic acid, (2-bromo-4-methylphenyl) ester; (2-Bromo-4-methylphenyl)isonitrile
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Methylphenylisocyanide is produced under stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and light-sensitive nature, store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.