Description

3-Isocyano-4-Methoxy-1,1'-Biphenyl is a specialized aromatic isocyanide derivative, serving as a versatile and high-value building block in advanced organic synthesis. Its unique bifunctional structure, featuring both an isocyano group and a methoxy-substituted biphenyl scaffold, makes it a critical precursor for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for constructing heterocyclic cores and functionalized biphenyl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the biphenyl moiety and reactive isocyano group enable the creation of compounds with specific biological activity.
• Ligand Synthesis for Catalysis: Serves as a starting material for the preparation of specialized N-heterocyclic carbene (NHC) ligands and other organometallic complexes used in transition metal catalysis.
• Material Science: Employed in the research of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated biphenyl system.
• Chemical Biology Probes: Utilized in click chemistry and bioorthogonal labeling strategies to create probes for studying biological processes, leveraging the reactivity of the isocyano group.

Basic Information

Product Name	3-Isocyano-4-Methoxy-1,1'-Biphenyl
CAS No.	730964-89-3
Molecular Formula	C14H11NO
Molecular Weight	209.24 g/mol
Synonyms	4-Methoxy-3-isocyanobiphenyl; 3-Isocyanato-4-methoxybiphenyl (common misnomer); 1,1'-Biphenyl, 3-isocyano-4-methoxy-; 4-Methoxy-[1,1'-biphenyl]-3-yl isocyanide; 3-Isocyano-4-methoxybiphenyl; 4-Methoxy-3-isocyanophenylbenzene
EINECS	Contact for details

Quality Control

Our 3-Isocyano-4-Methoxy-1,1'-Biphenyl is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, assay, and impurity profiles. Our quality systems are designed to support cGMP requirements for advanced pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to prevent degradation. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.