Description

1-Isocyano-4-Phenoxybenzene is a versatile isocyanide building block used in the synthesis of complex heterocyclic and pharmaceutical intermediates. Its value lies in enabling efficient multi-component reactions, such as the Ugi and Passerini reactions, which are pivotal for rapid library synthesis in drug discovery. This high-purity compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel compounds.

Application

• Pharmaceutical Intermediate: A key reactant in multi-component reactions (MCRs) for constructing diverse heterocyclic scaffolds central to medicinal chemistry programs.
• Agrochemical Synthesis: Used in the development of novel active ingredients, including fungicides and herbicides, by introducing the isocyano functional group.
• Ligand and Catalyst Precursor: Serves as a precursor for the synthesis of specialized isocyanide-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the creation of functional polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Utilized in bio-conjugation and labeling strategies due to the reactivity of the isocyano group.

Basic Information

Product Name	1-Isocyano-4-Phenoxybenzene
CAS No.	730964-87-1
Molecular Formula	C13H9NO
Molecular Weight	195.22 g/mol
Synonyms	4-Phenoxybenzyl isocyanide; 4-Phenoxyphenyl isocyanide; 1-Isocyanato-4-phenoxybenzene (common misnomer); Isocyano(4-phenoxyphenyl)methane; p-Phenoxybenzyl isocyanide; 4-Phenoxybenzenecarbonitrile, N-alkylidene; (4-Phenoxyphenyl)methyl isocyanide
EINECS	Contact for details

Quality Control

Our 1-Isocyano-4-Phenoxybenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, guaranteeing traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.