Description

2,5-Difluorobenzylisocyanide is a versatile and high-value organic building block, specifically an isocyanide derivative of a difluorinated benzyl group. This compound matters for its unique reactivity as a key three-component coupling partner in multicomponent reactions, enabling the efficient synthesis of complex heterocyclic scaffolds and pharmacophores. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery, medicinal chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of drug candidates, particularly for constructing nitrogen-containing heterocycles via Passerini or Ugi reactions.
• Medicinal Chemistry & Drug Discovery: Used to rapidly generate diverse compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems.
• Material Science Precursor: Serves as a building block for specialty polymers, ligands for catalysis, and advanced organic materials.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes and bioconjugation reagents for studying biological processes.
• Academic & Contract Research: Essential for methodological development in organic synthesis and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Item	Details
Product Name	2,5-Difluorobenzylisocyanide
CAS No.	730964-56-4
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	1-Isocyano-2,5-difluorobenzene; (2,5-Difluorophenyl)methyl isocyanide; 2,5-Difluorobenzyl isocyanide; 2,5-Difluorobenzyl Isonitrile; α-Isocyano-2,5-difluorotoluene; 2,5-Difluoro-α-isocyanotoluene; (2,5-Difluorobenzyl)isocyanide
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzylisocyanide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and chemical identity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality parameters. Our commitment is to supply material that meets the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term stability, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.