Description

2,4-Difluorobenzylisocyanide is a versatile and highly reactive organic building block, specifically an isocyanide derivative with a difluorinated benzyl group. Its value lies in its role as a critical precursor in multicomponent reactions, such as the Ugi and Passerini reactions, enabling the efficient synthesis of complex heterocyclic scaffolds and pharmacophores. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel compounds for drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and functional materials with specific electronic or surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel isocyanide-based ligands for catalysis and coordination chemistry applications.
• Combinatorial Chemistry: A valuable reagent in high-throughput synthesis and library generation for rapid screening of bioactive molecules.
• Chemical Biology Probes: Used to create activity-based probes or tags for studying biological processes and protein functions.

Basic Information

Product Name	2,4-Difluorobenzylisocyanide
CAS No.	730964-55-3
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	1-Isocyano-2,4-difluorobenzene; (2,4-Difluorophenyl)methyl isocyanide; 2,4-Difluorobenzyl isonitrile; 2,4-Difluorobenzyl Isocyanide; α-Isocyano-2,4-difluorotoluene; 2,4-Difluorobenzyl Isocyanide CAS 730964-55-3; 2,4-Difluorobenzyl Isocyanide (C8H5F2N)
EINECS	Contact for details

Quality Control

Our 2,4-Difluorobenzylisocyanide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place at a recommended temperature of 2-8°C. Keep the container tightly sealed under an inert atmosphere to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.