Description

2-Chloro-6-Fluorobenzylisocyanide is a versatile and highly reactive organic building block, specifically an isocyanide derivative of a halogenated benzyl group. This compound matters as a critical intermediate for constructing complex molecular architectures via multicomponent reactions, such as the Ugi and Passerini reactions, enabling efficient synthesis of heterocycles and pharmaceuticals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Agrochemical Research: Used in the development of new active ingredients for crop protection agents, leveraging its reactive isocyanide functionality.
• Ligand Synthesis: Serves as a precursor for the preparation of specialized ligands used in catalysis and coordination chemistry.
• Material Science: Employed in the creation of functionalized polymers and advanced organic materials with tailored properties.
• Multicomponent Reaction (MCR) Chemistry: An essential reactant in Ugi, Passerini, and related isocyanide-based multicomponent reactions for rapid library generation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes.

Basic Information

Product Name	2-Chloro-6-Fluorobenzylisocyanide
CAS No.	730964-52-0
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	2-Chloro-6-fluorobenzyl isocyanide; 1-Chloro-2-(isocyanomethyl)-3-fluorobenzene; (2-Chloro-6-fluorophenyl)methyl isocyanide; 2-Chloro-6-fluorobenzyl isonitrile; 2-Chloro-6-fluoro-α-isocyanotoluene; 730964-52-0; 2-Chloro-6-fluoro benzyl isocyanide
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluorobenzylisocyanide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent evaporation and potential moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.