Description

2,6-Difluorobenzylisocyanide is a versatile and highly reactive organic building block, specifically an isocyanide derivative of a difluorinated benzyl group. This compound matters for its role as a critical intermediate in the synthesis of complex heterocycles and functional molecules, particularly within modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in multicomponent reactions and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in the construction of heterocyclic scaffolds via Ugi and Passerini multicomponent reactions.
• Agrochemical Synthesis: Used in the development of new active ingredients for crop protection products, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized isocyanide-based ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functional polymers and advanced organic materials where the isocyanide group enables unique polymerization pathways.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and bio-conjugation reagents for studying biological systems.

Basic Information

Product Name	2,6-Difluorobenzylisocyanide
CAS No.	730964-51-9
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	1-Isocyano-2,6-difluorobenzene; (2,6-Difluorophenyl)methyl isocyanide; 2,6-Difluorobenzyl isonitrile; α-Isocyano-2,6-difluorotoluene; 2,6-Difluorobenzyl Isocyanide; 2,6-Difluorophenylmethylisocyanide
EINECS	Contact for details

Quality Control

Our 2,6-Difluorobenzylisocyanide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for use under cGMP conditions for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, well-ventilated place. Due to its sensitivity, keep away from strong oxidizing agents and moisture. For long-term storage, consider freezing at -20°C under inert gas.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.