Description

4-Chloro-2-Fluorobenzylisocyanide is a versatile and high-value aromatic isocyanide building block essential for modern synthetic chemistry. Its unique bifunctional structure, featuring both an isocyanide group and halogen substituents, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as multicomponent reactions and the synthesis of heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates via multicomponent reactions like the Ugi and Passerini reactions.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated aromatic core for bioactivity.
• Ligand and Catalyst Development: Serves as a building block for creating specialized isocyanide-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the preparation of functionalized polymers and advanced organic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tags for studying biological systems.
• Heterocyclic Compound Library Synthesis: A crucial reactant for generating diverse libraries of nitrogen-containing heterocycles for high-throughput screening.

Basic Information

Product Name	4-Chloro-2-Fluorobenzylisocyanide
CAS No.	730964-49-5
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	2-Fluoro-4-chlorobenzyl isocyanide; 1-Chloro-4-(isocyanomethyl)-3-fluorobenzene; (4-Chloro-2-fluorophenyl)methyl isocyanide; 4-Chloro-2-fluorobenzyl isonitrile; 2-Fluoro-4-chlorobenzylisonitrile; Benzene, 1-chloro-4-(isocyanomethyl)-3-fluoro-; Isocyanide, (4-chloro-2-fluorobenzyl)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorobenzylisocyanide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with global regulatory frameworks, and custom purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should be kept sealed under positive pressure of inert gas after opening. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.