Description

5-Bromo-2-Fluorobenzylisocyanide is a versatile and highly reactive aromatic isocyanide building block. This compound is critical for the efficient synthesis of complex heterocycles and functionalized molecules via multicomponent reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for lead optimization and the discovery of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of drug candidates, particularly for constructing heterocyclic cores prevalent in medicinal chemistry.
• Agrochemical Research: Used in the development of novel pesticides and herbicides through structure-activity relationship (SAR) studies.
• Material Science: Serves as a precursor for functionalized polymers and ligands for catalysis.
• Multicomponent Reactions (MCRs): Essential reactant in Passerini and Ugi-type reactions for the rapid generation of chemical diversity libraries.
• Chemical Biology: Employed in the synthesis of probes and tags for studying biological systems and protein interactions.
• Catalyst Ligand Synthesis: Building block for creating novel isocyanide-based ligands used in transition metal catalysis.

Basic Information

Product Name	5-Bromo-2-Fluorobenzylisocyanide
CAS No.	730964-48-4
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	1-Bromo-4-fluoro-2-(isocyanomethyl)benzene; 2-Fluoro-5-bromobenzyl isocyanide; (5-Bromo-2-fluorophenyl)methyl isocyanide; 5-Bromo-2-fluorobenzyl isonitrile; 2-Fluoro-5-bromobenzyl isonitrile; Isocyanomethyl-5-bromo-2-fluorobenzene; 730964-48-4
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluorobenzylisocyanide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.