Description

3-Bromo-4-Fluorobenzylisocyanide is a versatile and highly reactive aromatic isocyanide building block, essential for modern synthetic chemistry. Its unique bifunctional structure, featuring both a reactive isocyanide group and halogen substituents, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as multicomponent reactions and the synthesis of heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a precursor for functionalized polymers and advanced organic materials with tailored properties.
• Multicomponent Reactions (MCRs): An essential reactant in Passerini and Ugi-type reactions for the efficient, one-pot generation of compound libraries for high-throughput screening.
• Ligand and Catalyst Development: Employed in the synthesis of specialized isocyanide-based ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Used to create activity-based probes and other tools for studying biological processes and enzyme functions.

Basic Information

Product Name	3-Bromo-4-Fluorobenzylisocyanide
CAS No.	728920-04-5
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	1-Bromo-2-fluoro-4-(isocyanomethyl)benzene; 4-Fluoro-3-bromobenzyl isocyanide; (3-Bromo-4-fluorophenyl)methyl isocyanide; 3-Bromo-4-fluorobenzyl isonitrile; α-Isocyano-3-bromo-4-fluorotoluene; 3-Bromo-4-fluorobenzyl isocyanide; 4-Fluoro-3-bromobenzylisonitrile; 1-Fluoro-2-bromo-4-(isocyanomethyl)benzene
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluorobenzylisocyanide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to strong acids and organic solvents, keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.