Description

4-Bromo-2-Fluorobenzylisocyanide is a versatile and high-value aromatic isocyanide building block used in advanced organic synthesis. Its unique bifunctional structure, containing both a reactive isocyanide group and halogen substituents, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and materials science industries for applications such as multicomponent reactions and the synthesis of heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to create advanced fungicides, herbicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a building block for functional polymers, ligands for catalysis, and advanced organic frameworks (MOFs/COFs).
• Multicomponent Reactions (MCRs): An essential reactant in Passerini and Ugi-type reactions for the efficient, one-pot generation of compound libraries.
• Heterocyclic Chemistry: Employed in the construction of complex nitrogen-containing heterocycles, such as imidazoles and oxazoles, which are common pharmacophores.
• Chemical Biology & Proteomics: Used as a probe or tag in bioorthogonal chemistry and activity-based protein profiling (ABPP) studies.

Basic Information

Product Name	4-Bromo-2-Fluorobenzylisocyanide
CAS No.	728920-03-4
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	1-Bromo-4-(isocyanomethyl)-2-fluorobenzene; 2-Fluoro-4-bromobenzyl isocyanide; 4-Bromo-2-fluorobenzyl isonitrile; (4-Bromo-2-fluorophenyl)methyl isocyanide; 4-Bromo-2-fluoro-α-isocyano-toluene; 2-Fluoro-4-bromobenzylisocyanide; 4-Bromo-2-fluorobenzyl isocyanide; 4-Bromo-2-fluorobenzylisonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluorobenzylisocyanide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and moisture absorption. Isolate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.