Description

2-(4-Nitro-Phenyl)-3-Piperazin-1-Ylmethyl-Imidazo-[1,2-A]Pyridine CAS NO 728864-97-9 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its imidazopyridine and piperazine motifs.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Biochemical Tool Compound: Serves as a reference standard or a precursor for labeled compounds in pharmacological assays and diagnostic research.
• Academic Research: Utilized in university and institutional labs for exploring new heterocyclic chemistry and reaction methodologies.

Basic Information

Product Name	2-(4-Nitro-Phenyl)-3-Piperazin-1-Ylmethyl-Imidazo-[1,2-A]Pyridine
CAS No.	728864-97-9
Molecular Formula	C19H19N5O2
Molecular Weight	349.39 g/mol
Synonyms	2-(4-Nitrophenyl)-3-(piperazin-1-ylmethyl)imidazo[1,2-a]pyridine; 3-[(Piperazin-1-yl)methyl]-2-(4-nitrophenyl)imidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 2-(4-nitrophenyl)-3-(1-piperazinylmethyl)-; 728864-97-9; 2-(4-Nitrophenyl)-3-(piperazin-1-ylmethyl)-imidazo[1,2-a]pyridine; 3-(Piperazin-1-ylmethyl)-2-(4-nitrophenyl)imidazo[1,2-a]pyridine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and traceability. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ validated analytical methods, including HPLC, GC, NMR, and mass spectrometry, to confirm specifications. Quality systems are designed to support development through commercial scale, with documentation available for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider under an inert atmosphere such as nitrogen or argon. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.