Description

1-[2-(4-Fluoro-Phenyl)-8-Methyl-Imidazo[1,2-A]-Pyridin-3-Ylmethyl]-Piperidine-4-Carboxylic Acid CAS NO 727977-66-4 is a high-purity, advanced pharmaceutical intermediate belonging to the imidazopyridine class of heterocyclic compounds. This compound is of significant value for its role as a key building block in the research and development of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and psychiatric disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially for central nervous system (CNS) targets.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in the manufacturing process of potential APIs for clinical trials.
• Biochemical Research: Employed as a tool compound in pharmacological assays to study receptor binding and enzyme inhibition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	1-[2-(4-Fluoro-Phenyl)-8-Methyl-Imidazo[1,2-A]-Pyridin-3-Ylmethyl]-Piperidine-4-Carboxylic Acid
CAS No.	727977-66-4
Molecular Formula	C22H22FN3O2
Molecular Weight	379.43 g/mol
Synonyms	1-({2-(4-Fluorophenyl)-8-methylimidazo[1,2-a]pyridin-3-yl}methyl)piperidine-4-carboxylic acid; 1-[[2-(4-Fluorophenyl)-8-methylimidazo[1,2-a]pyridin-3-yl]methyl]-4-piperidinecarboxylic acid; 727977-66-4; UNII-6J6U9Q2V6F; 6J6U9Q2V6F; 1-({2-(4-Fluorophenyl)-8-methylimidazo[1,2-a]pyridin-3-yl}methyl)piperidine-4-carboxylic acid; 1-[[2-(4-Fluorophenyl)-8-methylimidazo[1,2-a]pyridin-3-yl]methyl]isonipecotic acid
EINECS	Contact for details

Quality Control

Our production of 1-[2-(4-Fluoro-Phenyl)-8-Methyl-Imidazo[1,2-A]-Pyridin-3-Ylmethyl]-Piperidine-4-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.