Description

1-[2-(4-Fluoro-Phenyl)-Imidazo[1,2-A]Pyridin-3-Ylmethyl]-Piperidine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and development programs, particularly those focused on central nervous system (CNS) and metabolic disorders.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates targeting specific biological pathways.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in early-stage R&D.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold for constructing final API molecules in pre-clinical and clinical development batches.
• Biochemical Research: Employed as a tool compound or ligand in biochemical assays to study enzyme inhibition or receptor binding.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	1-[2-(4-Fluoro-Phenyl)-Imidazo[1,2-A]Pyridin-3-Ylmethyl]-Piperidine-4-Carboxylic Acid
CAS No.	727977-52-8
Molecular Formula	C20H20FN3O2
Molecular Weight	353.39 g/mol
Synonyms	1-[[2-(4-Fluorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]-4-piperidinecarboxylic acid; 4-Piperidinecarboxylic acid, 1-[[2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]-; UNII-1Q8K2S8F8V; 1Q8K2S8F8V; 727977-52-8; 1-({2-[4-Fluorophenyl]imidazo[1,2-a]pyridin-3-yl}methyl)piperidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical characterization using techniques including HPLC, NMR, and MS to ensure structural identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support development and commercial projects with material produced under quality agreements and can supply material suitable for use under cGMP guidelines for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.