Description

4-(Benzyloxy)-2-Bromonicotinonitrile is a high-purity brominated nicotinonitrile derivative, serving as a versatile and critical building block in advanced organic synthesis. Its molecular structure, featuring both a benzyloxy protecting group and a reactive bromine atom, makes it an indispensable intermediate for constructing complex heterocyclic frameworks. This compound is primarily sought after by research institutions and pharmaceutical development companies engaged in medicinal chemistry, particularly for the synthesis of novel drug candidates and agrochemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting kinase inhibition or other nicotinamide-based biological pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require substituted pyridine cores for enhanced activity.
• Material Science: Building block for creating specialized ligands, catalysts, and organic electronic materials due to its electron-deficient aromatic system.
• Chemical Synthesis: Serves as a versatile substrate for cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to introduce diverse functional groups.
• Academic & Contract Research: Essential reagent for methodological development and exploratory research in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	4-(Benzyloxy)-2-Bromonicotinonitrile
CAS No.	727737-51-1
Molecular Formula	C13H9BrN2O
Molecular Weight	289.13 g/mol
Synonyms	2-Bromo-4-(benzyloxy)nicotinonitrile; 4-Benzyloxy-2-bromonicotinonitrile; 2-Bromo-4-(phenylmethoxy)-3-pyridinecarbonitrile; Nicotinonitrile, 2-bromo-4-(benzyloxy)-; 3-Pyridinecarbonitrile, 2-bromo-4-(phenylmethoxy)-
EINECS	Contact for details

Quality Control

Every batch of 4-(Benzyloxy)-2-Bromonicotinonitrile is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, with comprehensive analysis performed using advanced techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.