Description

3-(2-([1,1'-Biphenyl]-4-Yl)-2-Oxoethyl)-1,3-Diazaspiro[4.5]Decane-2,4-Dione is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and biphenyl-based molecular architecture. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders or oncological pathways.
• Drug Discovery & Medicinal Chemistry: Used as a versatile scaffold for constructing compound libraries in high-throughput screening (HTS) campaigns to identify new bioactive molecules.
• Process Research & Development (R&D): Employed in route scouting and optimization studies for the scalable production of target APIs under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Acts as a core structure for developing specialized probes to study enzyme mechanisms or protein-ligand interactions in biochemical assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	3-(2-([1,1'-Biphenyl]-4-Yl)-2-Oxoethyl)-1,3-Diazaspiro[4.5]Decane-2,4-Dione
CAS No.	727718-78-7
Molecular Formula	C24H24N2O3
Molecular Weight	388.46 g/mol
Synonyms	1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[2-(4-biphenylyl)-2-oxoethyl]-; 3-(2-([1,1'-Biphenyl]-4-yl)-2-oxoethyl)-1,3-diazaspiro[4.5]decane-2,4-dione; Biphenyl-spirodione derivative; Spirocyclic hydantoin biphenyl derivative; CAS 727718-78-7; (Alternative IUPAC) 3-[2-(4-Phenylphenyl)-2-oxoethyl]-1,3-diazaspiro[4.5]decane-2,4-dione
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up work. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We implement analytical methods including HPLC, GC, NMR, and MS to verify specifications. Quality systems are designed to support development under ISO and cGMP frameworks as required by our global pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.