Description

(4-Piperazin-1-Yl-Phenyl)-Pyridin-4-Yl-Methanone CAS NO 727658-85-7 is a high-purity, advanced pharmaceutical intermediate featuring a distinct piperazine-phenyl-pyridinyl ketone structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new molecular entities.
• CNS Drug Development: Serves as a core scaffold for compounds being investigated for neurological and psychiatric disorders.
• Oncology Research: Employed in the development of kinase inhibitors and other targeted cancer therapies.
• Chemical Biology: Utilized as a probe or tool compound for studying biological mechanisms and protein interactions.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	(4-Piperazin-1-Yl-Phenyl)-Pyridin-4-Yl-Methanone
CAS No.	727658-85-7
Molecular Formula	C16H17N3O
Molecular Weight	267.33 g/mol
Synonyms	4-(4-Piperazin-1-ylphenyl)pyridin-4-ylmethanone; 1-[4-(4-Pyridinylcarbonyl)phenyl]piperazine; (4-Piperazin-1-ylphenyl)(pyridin-4-yl)methanone; 4-Piperazin-1-yl-benzoic acid pyridin-4-ylmethylene ester; 727658-85-7; 4-(Piperazin-1-yl)phenyl(pyridin-4-yl)methanone; 4-(4-Piperazin-1-ylbenzoyl)pyridine
EINECS	Contact for details

Quality Control

Our (4-Piperazin-1-Yl-Phenyl)-Pyridin-4-Yl-Methanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.