Description

3-(6-Bromo-2-Phenyl-Imidazo[1,2-A]Pyridin-3-Yl)-Acrylic Acid CAS NO 727652-45-1 is a high-purity, advanced pharmaceutical intermediate characterized by its distinct imidazo[1,2-a]pyridine core functionalized with an acrylic acid moiety. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and antiviral domains.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the development of fluorescent or affinity-based probes to study biological pathways and protein function.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions and cyclization strategies to construct complex heterocyclic systems.
• Agrochemical Research: Investigated as an intermediate for developing new active ingredients with potential herbicidal or fungicidal properties.
• Material Science: Explored as a monomer or functional additive for specialty polymers with unique optical or electronic properties.

Basic Information

Product Name	3-(6-Bromo-2-Phenyl-Imidazo[1,2-A]Pyridin-3-Yl)-Acrylic Acid
CAS No.	727652-45-1
Molecular Formula	C₁₆H₁₁BrN₂O₂
Molecular Weight	343.18 g/mol
Synonyms	3-(6-Bromo-2-phenylimidazo[1,2-a]pyridin-3-yl)prop-2-enoic acid; (E)-3-(6-Bromo-2-phenylimidazo[1,2-a]pyridin-3-yl)acrylic acid; 6-Bromo-2-phenyl-3-(2-propenoyl)imidazo[1,2-a]pyridine; 727652-45-1; BR-IMIDAZO-PYRIDINE-ACRYLIC ACID; AKOS BRN-0719; 3-(6-Bromo-2-phenyl-1H-imidazo[1,2-a]pyridin-3-yl)acrylic acid
EINECS	Contact for details

Quality Control

Our production of 3-(6-Bromo-2-Phenyl-Imidazo[1,2-A]Pyridin-3-Yl)-Acrylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.