Description

3-[6-Bromo-2-(4-Fluoro-Phenyl)-Imidazo[1,2-A]-Pyridin-3-Yl]-Acrylic Acid is a high-value, multi-functional heterocyclic building block designed for advanced organic synthesis. This compound is critical for research and development in medicinal chemistry, offering a versatile scaffold for creating novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers developing next-generation small molecule therapeutics and high-performance materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in oncology and CNS (Central Nervous System) therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis due to its imidazopyridine and acrylic acid functionalities.
• Agrochemical Development: Employed in the research and synthesis of new-generation pesticides and herbicides, leveraging its halogenated aromatic structure.
• Chemical Biology Probes: Utilized in the development of fluorescent tags or activity-based probes for studying biological pathways and target engagement.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers with unique optical or electronic properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and custom synthesis projects.

Basic Information

Product Name	3-[6-Bromo-2-(4-Fluoro-Phenyl)-Imidazo[1,2-A]-Pyridin-3-Yl]-Acrylic Acid
CAS No.	727652-42-8
Molecular Formula	C₁₆H₁₀BrFN₂O₂
Molecular Weight	361.17 g/mol
Synonyms	3-(6-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)acrylic acid; 2-Propenoic acid, 3-[6-bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-; (E)-3-(6-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)acrylic acid; 6-Bromo-2-(4-fluorophenyl)-3-(2-carboxyvinyl)imidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine-3-acrylic acid, 6-bromo-2-(4-fluorophenyl)-; CAS 727652-42-8
EINECS	Contact for details

Quality Control

Our 3-[6-Bromo-2-(4-Fluoro-Phenyl)-Imidazo[1,2-A]-Pyridin-3-Yl]-Acrylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is compatible with strong acids and organic solvents but should be handled with appropriate personal protective equipment in a fume hood. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.