Description

(3S)-4-Chloro-3-[(Trimethylsilyl)Oxy]Butanenitrile is a high-value, chiral synthetic intermediate of significant importance in modern pharmaceutical and fine chemical research. Its core value proposition lies in its unique molecular structure, which serves as a versatile building block for the stereoselective synthesis of complex bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing active pharmaceutical ingredients (APIs) and novel therapeutic agents that require precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, including potential antiviral, anticancer, and neurological agents.
• Asymmetric Synthesis: Used in the construction of stereogenic centers for the production of enantiomerically pure compounds (EPCs) in fine chemical manufacturing.
• Agrochemical Research: Serves as a precursor in the development of novel, chiral pesticides and herbicides with improved efficacy and selectivity.
• Peptidomimetics & Amino Acid Derivatives: A valuable starting material for the preparation of non-natural amino acids and peptide analogs used in medicinal chemistry.
• Catalyst & Ligand Development: Employed in the research and synthesis of new chiral catalysts and ligands for asymmetric catalysis.
• Academic & R&D Laboratories: A critical reagent for methodological development in organic synthesis and stereochemistry studies.

Basic Information

Product Name	(3S)-4-Chloro-3-[(Trimethylsilyl)Oxy]Butanenitrile
CAS No.	727382-14-1
Molecular Formula	C7H14ClNOSi
Molecular Weight	191.73 g/mol
Synonyms	(3S)-4-Chloro-3-(trimethylsilyloxy)butyronitrile; (S)-4-Chloro-3-((trimethylsilyl)oxy)butanenitrile; 4-Chloro-3-[(trimethylsilyl)oxy]butanenitrile, (3S)-; Butanenitrile, 4-chloro-3-[(trimethylsilyl)oxy]-, (3S)-; (S)-4-Chloro-3-(trimethylsiloxy)butyronitrile; (3S)-4-Chloro-3-(TMS-oxy)butanenitrile; (S)-4-Chloro-3-(TMSO)butyronitrile; (3S)-4-Chloro-3-(trimethylsilyloxy)butyronitrile
EINECS	Contact for details

Quality Control

Our (3S)-4-Chloro-3-[(Trimethylsilyl)Oxy]Butanenitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We employ advanced analytical techniques including HPLC, GC, and chiral analysis to verify chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.